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HLA‐DR and DQ polymorphisms in bullous pemphigoid from northern China
Author(s) -
Gao X.H.,
Winsey S.,
Li G.,
Barnardo M,
Zhu X.J.,
Chen H.D.,
Song F.,
Zhai N.,
Fuggle S.,
Wojnarowska F.
Publication year - 2002
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.2002.01037.x
Subject(s) - haplotype , bullous pemphigoid , hla dq , immunology , autoantibody , allele , genotype , human leukocyte antigen , hla dr , biology , genetics , medicine , gene , antibody , antigen
Summary Bullous pemphigoid (BP) is an autoimmune disease mediated by autoantibodies against hemidesmosome components. This study used PCR–sequence‐specific primers to genotype polymorphisms in HLA‐DR and DQ in 25 BP patients and 57 normal controls from northern China. We found lower frequencies of DRB1*08 (DR8) and DRB1*08/DQB1*06 (DR8/DQ6) haplotypes in BP patients than in controls (4.08% vs. 15.19% and 1.54% vs. 13.82%, respectively; P < 0.05), suggesting a protective role for DR8 and DR8/DQ6 haplotypes in BP patients from northern China; there were no statistical differences among other alleles tested. This result is strikingly different from previous reports that DQB1*0301 is associated with BP in Caucasian patients and DRB1*1101, DQB1*0302, DRB1*04/DQA1*0301/DQB1*0302 and DRB1*1101/ DQA1*0505/DQB1*0302 with Japanese BP patients. Ethnic differences in the polymorphic composition of the HLA‐DR and DQ genes may influence genetic susceptibility to BP.