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Successful treatment of severe recalcitrant psoriasis with combination infliximab and methotrexate
Author(s) -
Kirby B.,
Marsland A. M.,
Carmichael A. J.,
Griffiths C. E. M.
Publication year - 2001
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.2001.00753.x
Subject(s) - medicine , dermatology , infliximab , psoriasis , university hospital , family medicine , library science , disease , computer science
Plaques of psoriasis contain increased levels of cytokines, including tumour necrosis factor‐alpha (TNF‐α), which are thought to be essential to the maintenance of the psoriatic process. We report the successful treatment of severe, recalcitrant psoriasis when infliximab (a monoclonal antibody to TNF‐α) was used in combination with methotrexate.