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Influence of antithymocyte globulin dose on outcome in cytomegalovirus‐seropositive recipients of partially T cell‐depleted stem cell grafts from matched‐unrelated donors
Author(s) -
Meijer Ellen,
Dekker Adriaan W.,
Verdonck Leo F.
Publication year - 2003
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2003.04294.x
Subject(s) - serostatus , cytomegalovirus , transplantation , medicine , betaherpesvirinae , immunology , globulin , herpesviridae , gastroenterology , viral disease , virus , viral load
Summary. The adverse impact of positive‐recipient Cytomegalovirus (CMV) serostatus on the outcome of matched‐unrelated donor (MUD) grafts has been stressed. We evaluated whether CMV‐seropositive MUD recipients transplanted after 1999 still showed inferior outcome compared with CMV‐seronegative recipients. Two important changes in transplantation procedure were introduced in 1999: (1) reduction of antithymocyte globulin dose, (2) introduction of sequence‐based typing of HLA‐DRB1. Thirty‐six patients received partial T cell‐depleted grafts before 1999, and 44 after 1999. CMV‐seropositive patients transplanted before 1999 showed a highly significant inferior outcome compared with seronegative recipients. In contrast, no difference in outcome was observed between the two groups of patients transplanted after 1999.