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Inherited factor VII deficiency and surgery: clinical data are the best criteria to predict the risk of bleeding
Author(s) -
Blaizot Muriel Giansily,
BironAndreani Christine,
AguilarMartinez Patricia,
De Moeloose Philippe,
Briquel MarieElisabeth,
Goudemand Jenny,
Stieltjes Nathalie,
Barrot Claire,
Chambost Herve,
Durin Anne,
Gay Valerie,
Peynet Jocelyne,
Pouymayou Katia,
Schved JeanFrançois
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.2002.03408.x
Subject(s) - medicine , factor vii , severe bleeding , surgery , risk factor , coagulation
Summary. Inherited factor VII (FVII) deficiency is a rare autosomal disorder characterized by a weak relationship between FVII activity (FVII:C) and operative bleeding risk. We report a retrospective study of 17 patients with a FVII:C below 0·1 IU/ml, in whom surgery was performed without any replacement therapy. Clinical and biological data were analysed to establish predictive criteria for bleeding tendency. We found that systematic preoperative replacement therapy may not be necessary for ‘minor’ surgical procedures, for patients suffering from inherited FVII deficiency, unless the clinical history includes severe haemorrhagic symptoms such as haemarthrosis, severe haematomas (even of soft tissue) or abundant epistaxis.