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A new preconditioning regimen with melphalan, busulphan and total body irradiation followed by low‐dose immunosuppressant in allogeneic haemopoietic stem cell transplantation
Author(s) -
Murata Makoto,
Nishida Tetsuya,
Haneda Masataka,
Kanie Tadaharu,
Taji Hirofumi,
Iida Hiroatsu,
Suzuki Ritsuro,
Hamaguchi Motohiro,
Minami Saburo,
Kodera Yoshihisa
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.1365-2141.1999.01424.x
Subject(s) - melphalan , medicine , total body irradiation , regimen , transplantation , methotrexate , gastroenterology , surgery , busulfan , hematopoietic stem cell transplantation , tacrolimus , chemotherapy , stem cell , urology , cyclophosphamide , biology , genetics
Twenty adult patients with high‐risk leukaemia underwent allogeneic haemopoietic stem cell transplantation after melphalan, busulphan and total body irradiation followed by short‐term methotrexate and low‐dose cyclosporine or tacrolimus. Three patients developed veno‐occlusive disease and no patient developed renal dysfunction. Seven patients experienced grade II–IV acute graft‐versus‐host disease (aGVHD) and five patients experienced grade III–IV. The 3‐year probabilities of relapse and leukaemia‐free survival were 22 ± 11% (95% confidence interval) and 50 ± 11%, respectively. These data suggest that this preconditioning regimen followed by a low‐dose immunosuppressant provided a more anti‐leukaemic effect without increased regimen‐related toxicity and aGVHD.