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Comparison of adapalene 0·1% solution and tretinoin 0·025% gel in the topical treatment of acne vulgaris
Author(s) -
Charles N. Ellis,
Larry E. Millikan,
Edgar B. Smith,
D. M. Chalker,
Leonard J. Swinyer,
Irving Katz,
Richard S. Berger,
Otto H. Mills,
Michael Baker,
Michèle Verschoore,
Christian Loesche
Publication year - 1998
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1046/j.1365-2133.1998.1390s2041.x
Subject(s) - adapalene , acne , tretinoin , dermatology , medicine , dermatologic agents , chemistry , retinoic acid , antibiotics , organic chemistry , biochemistry , benzoyl peroxide , polymerization , gene , polymer
A multicentre study was conducted to compare clinical safety and efficacy of adapalene 0·1% solution and tretinoin 0·025% gel, both topical treatments for acne, in a once‐daily dosage regimen for 12 weeks. A total of 297 patients were enrolled by eight investigators in this randomized, investigator‐masked study in a parallel group design. An open label period using adapalene followed this study to assess the long‐term safety of adapalene solution. Adapalene and tretinoin proved to be clinically and statistically effective in treating acne by reducing inflammatory (47% and 50%, respectively) and non‐inflammatory lesions (57% and 54%) as compared to baseline. When comparing patients who had 75% or greater improvement in open comedones, adapalene was shown to be significantly more effective than tretinoin. No serious adverse event was reported during this study, including during the long‐term period. The reactions that occurred were similar between treatments, i.e. burning, pruritus, scaling, dryness and erythema.