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The pharmacokinetics of trinitroglycerin and its metabolites in patients with chronic stable angina
Author(s) -
Hashimoto Satoru,
Yamauchi Eiko,
Kobayashi Atsuko,
Shigemi Kenji,
Tsuruta Hiroshi,
Yamashita Tomomitsu,
Tanaka Yoshifumi
Publication year - 2000
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.1365-2125.2000.00263.x
Subject(s) - pharmacokinetics , medicine , transdermal , pharmacology , anesthesia , intravenous infusions , angina , route of administration , myocardial infarction
Aims To study the pharmacokinetics of trinitroglycerin (GTN) and its four metabolites in angina patients during their transient use of transdermal GTN tape following intravenous administration of GTN.Methods Four patients received a GTN tape following intravenous administration of 0.1 µg kg −1 min −1 GTN, and the other four patients received two GTN tapes following intravenous administration of 0.2 µg kg −1 min −1 GTN.Results Plasma concentrations of GTN in both groups during tape application showed a slight decrease for the hour after the application of the tape and then were con‐ stant for 24 h. In contrast, the concentrations of dinitroglycerins (GDNs) and mononitroglycerins (GMNs) depended on the duration of previous intravenous administration of GTN. Neither significant cardiovascular changes nor undesirable complications were observed during the study.Conclusions The results suggest that appropriate replacement of intravenous GTN administration with transdermal tape application could maintain a therapeutic GTN level.