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Melanocortin‐4 receptor (MC4R) genotypes have no major effect on fatness in a Large White × Wild Boar intercross
Author(s) -
Park H. B.,
Carlborg Ö.,
Marklund S.,
Andersson L.
Publication year - 2002
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1046/j.1365-2052.2002.00824.x
Subject(s) - biology , missense mutation , melanocortin 4 receptor , genetics , allele , boar , wild boar , genotype , melanocortin , endocrinology , gene , medicine , mutation , receptor , ecology , sperm
The melanocortin‐4 receptor ( MC4R ), a G‐protein coupled receptor, is implicated in mediating the effect of leptin on food intake and energy balance. A previous candidate gene study reported an association between an MC4R missense mutation (Asp298Asn) and fatness, growth and feed intake in pigs. To assess this association further, we analysed the segregation of this missense mutation in relation to variation in fatness traits using a Wild Boar × Large White intercross. The Wild Boar and Large White founders were homozygous for different MC4R alleles. The MC4R was assigned to the expected region on pig chromosome 1. The statistical evaluation did not reveal any indication of a significant effect on fatness related traits in this pedigree.