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Genetic mapping of a locus associated with bovine chronic interstitial nephritis to chromosome 1
Author(s) -
Kobayashi N,
Hirano T,
Maruyama S,
Matsuno H,
Mukoujima K,
Morimoto H,
Noike H,
Tomimatsu H,
Hara K,
Itoh T,
Imakawa K,
Nakayama H,
Nakamaru T,
Sugimoto Y
Publication year - 2000
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1046/j.1365-2052.2000.00589.x
Subject(s) - biology , microsatellite , locus (genetics) , genetics , genetic marker , gene mapping , chromosome , gene , allele
Chronic interstitial nephritis with diffuse zonal fibrosis (CINF) occurs in Japanese Black cattle (Wagyu) as an autosomal recessive disorder leading to death prior to puberty, first six months or a year of life. We performed a genome‐wide scan using microsatellite markers in a Wagyu pedigree segregating for CINF and mapped the CINF locus to bovine chromosome 1. CINF was closest to microsatellites BM9019 and INRA49 (Z score = 12 ·0; P < 3 ·4 × 10 −10 ).