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Comparison of remifentanil with alfentanil or suxamethonium following propofol anaesthesia for tracheal intubation[Note 1. This work has been presented in part at the ...]
Author(s) -
Alexander R.,
Booth J.,
Olufolabi A. J.,
ElMoalem H. E.,
Glass P. S.
Publication year - 1999
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1046/j.1365-2044.1999.01070.x
Subject(s) - remifentanil , alfentanil , medicine , propofol , anesthesia , tracheal intubation , bolus (digestion) , intubation , hemodynamics , heart rate , surgery , blood pressure
Sixty ASA physical status I and II, premedicated patients were administered propofol 2 mg.kg −1 and remifentanil 2 μg.kg −1 (group R), alfentanil 50 μg.kg −1 (group A) or suxamethonium 1 mg.kg −1 (group S) as a rapid bolus. One minute after study drug administration, tracheal intubation was performed. Intubation conditions were then scored. Excellent or good conditions were observed in only 35% in group R compared with groups S and A (100% and 85%, respectively; p < 0.001). The haemodynamic response to tracheal intubation was blunted in groups R and A compared with group S (p < 0.001). The mean heart rate in groups R and A was significantly lower than group S (p < 0.001). We conclude that remifentanil 2 μg.kg −1 given as a rapid bolus will not produce intubating conditions as good as those obtained with alfentanil 50 μg.kg −1 or suxamethonium 1 mg.kg −1 if administered after propofol 2 mg.kg −1 .