Immune responses in hepatitis C virus infection: The role of dendritic cells | Zendy

Fowler Nina L | Zendy; Torresi Joseph | Zendy; Jackson David C | Zendy; Brown Lorena E | Zendy; Gowans Eric J | Zendy

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Immune responses in hepatitis C virus infection: The role of dendritic cells

Author(s) -

Fowler Nina L,

Torresi Joseph,

Jackson David C,

Brown Lorena E,

Gowans Eric J

Publication year - 2003

Publication title -

immunology and cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.999

H-Index - 104

eISSN - 1440-1711

pISSN - 0818-9641

DOI - 10.1046/j.0818-9641.2002.01138.x

Subject(s) - immune system , dendritic cell , immunotherapy , antigen presentation , virology , immunology , biology , virus , antigen , hepatitis c virus , cd8 , cytotoxic t cell , antigen presenting cell , t cell , in vitro , biochemistry

Cellular immune responses are critical for the clearance of hepatitis C virus. Persistent infection results from a narrow and weak cellular immune response, in direct contrast to the broad, strong response associated with viral clearance in acute infection. The presence of dendritic cells in the liver facilitates presentation of viral antigens to both CD4 + and CD8 + T cell populations. Exploiting the potent antigen presentation capability of dendritic cells for immunotherapy of chronic hepatitis C is attractive; however, infection or transfection of segments or the entire hepatitis C virus genome appears to impair the allostimulation capacity of dendritic cells. If dendritic cell immunotherapy for hepatitis C virus infection is to become a reality, the mechanism behind the defective allostimulatory capacity needs to be deciphered.

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