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Adverse drug reactions in patients admitted to hospital identified by discharge ICD‐10 codes and by spontaneous reports
Author(s) -
Cox A. R.,
Anton C.,
Goh C. H. F.,
Easter M.,
Langford N. J.,
Ferner R. E.
Publication year - 2001
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.0306-5251.2001.01454.x
Subject(s) - medicine , drug reaction , hospital discharge , icd 10 , adverse drug reaction , adverse effect , pediatrics , emergency medicine , coding (social sciences) , drug , family medicine , psychiatry , statistics , mathematics
Aims We studied the international classification of disease (ICD) hospital discharge codes to find unreported adverse drug reactions (ADRs), and asked doctors about their attitudes to reporting some of these cases. Methods We examined the ICD codes assigned on discharge to identify ADRs and compared these with spontaneous reports made to the Committee on Safety of Medicines (CSM). Doctors involved were sent brief résumés of cases and asked if they would report them. Results 49 of 21 365 patient episodes were coded on discharge as ADRs, of which 33 were ‘reportable’. Fourteen spontaneous reports were received by the CSM during the same period. The two groups did not overlap. 25 of 60 doctors responded to our questionnaire, and would have reported only 8 of 75 cases outlined. Conclusions The ICD coding allowed us to identify important ADRs which most doctors would not report spontaneously.