Open AccessMechanisms of Aminoglycoside- and Cisplatin-Induced Ototoxicity
Author(s) -
Peter S. Steyger
Publication year - 2021
Publication title -
american journal of audiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.688
H-Index - 45
eISSN - 1558-9137
pISSN - 1059-0889
DOI - 10.1044/2021_aja-21-00006
Subject(s) - ototoxicity , hearing loss , medicine , aminoglycoside , intensive care medicine , audiology , quality of life (healthcare) , antibiotics , cisplatin , surgery , chemotherapy , microbiology and biotechnology , nursing , biology
Purpose This review article summarizes our current understanding of the mechanisms underlying acquired hearing loss from hospital-prescribed medications that affects as many as 1 million people each year in Western Europe and North America. Yet, there are currently no federally approved drugs to prevent or treat the debilitating and permanent hearing loss caused by the life-saving platinum-based anticancer drugs or the bactericidal aminoglycoside antibiotics. Hearing loss has long-term impacts on quality-of-life measures, especially in young children and older adults. This review article also highlights some of the current knowledge gaps regarding iatrogenic causes of hearing loss. Conclusion Further research is urgently needed to further refine clinical practice and better ameliorate iatrogenic drug-induced hearing loss.