Open AccessMapping of truncated O-glycans in cancers of epithelial and non-epithelial origin
Author(s) -
Troels Boldt Rømer,
Mikkel Koed Møller Aasted,
Sally Dabelsteen,
A. S. Groen,
Julia A. Schnabel,
Edwin S. Tan,
Jacob Pedersen,
Amalie Dahl Haue,
Hans H. Wandall
Publication year - 2021
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-021-01530-7
Subject(s) - colorectal cancer , pancreas , cancer research , pancreatic cancer , antigen , cancer , biology , immunohistochemistry , monoclonal antibody , pathology , antibody , medicine , immunology , endocrinology
Novel immunotherapies targeting cancer-associated truncated O-glycans Tn (GalNAcα-Ser/Thr) and STn (Neu5Acα2-6GalNacα-Ser/Thr) are promising strategies for cancer treatment. However, no comprehensive, antibody-based mapping of truncated O-glycans in tumours exist to guide drug development.