Open AccessDiagnostic accuracy of circulating-free DNA for the determination of MYCN amplification status in advanced-stage neuroblastoma: a systematic review and meta-analysis
Author(s) -
Ricky M Trigg,
Suzanne Turner,
Jacqueline Shaw,
Leila Jahangiri
Publication year - 2020
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/s41416-020-0740-y
Subject(s) - diagnostic odds ratio , meta analysis , stage (stratigraphy) , medicine , oncology , bivariate analysis , neuroblastoma , odds ratio , diagnostic accuracy , biology , genetics , statistics , paleontology , mathematics , cell culture
MYCN amplification (MNA) is the strongest indicator of poor prognosis in neuroblastoma (NB). This meta-analysis aims to determine the diagnostic accuracy of MNA analysis in circulating-free DNA (cfDNA) from advanced-stage NB patients.