Open AccessTargeting T-cell oxidative metabolism to improve influenza survival in a mouse model of obesity
Author(s) -
Yazan Alwarawrah,
Amanda Nichols,
William D. Green,
William Eisner,
Kaitlin Kiernan,
Jonathan L. Warren,
Laura P. Hale,
Melinda A. Beck,
Nancie J. MacIver
Publication year - 2020
Publication title -
international journal of obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.663
H-Index - 225
eISSN - 1476-5497
pISSN - 0307-0565
DOI - 10.1038/s41366-020-00692-3
Subject(s) - immune system , adipose tissue , endocrinology , medicine , t cell , metformin , biology , cd8 , diet induced obese , cytotoxic t cell , immunology , insulin resistance , diabetes mellitus , in vitro , biochemistry
Obesity is associated with impaired primary and secondary immune responses to influenza infection, with T cells playing a critical role. T-cell function is highly influenced by the cellular metabolic state; however, it remains unknown how altered systemic metabolism in obesity alters T-cell metabolism and function to influence immune response. Our objective was to identify the altered cellular metabolic state of T cells from obese mice so that we may target T-cell metabolism to improve immune response to infection.