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Electroencephalographic and behavioral correlates of buprenorphine administration
Author(s) -
Lukas Scott E,
Jasinski Donald R,
Johnson Rolley E
Publication year - 1984
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1984.150
Subject(s) - buprenorphine , methadone , clinical pharmacology , electroencephalography , mood , opiate , psychology , anesthesia , partial agonist , medicine , agonist , pharmacology , psychiatry , opioid , receptor
Male subjects on methadone maintenance who were residing in a research ward were switched to buprenorphine for 45 days. Physiologic measures, behavioral and subjective ratings of mood states, and an electroencephalogram (EEG) were obtained daily. Distinct changes in EEG activity paralleled physiologic and behavioral effects during the transition to buprenorphine. Sinular physiologic effects and a reversal of EEG effects occurred when saline solution was substituted for buprenorphine. It is concluded that, consistent with its classification as a partial opiate agonist, buprenorphine may not substitute fully for methadone. Clinical Pharmacology and Therapeutics (1984) 36, 127–132; doi: 10.1038/clpt.1984.150