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Correlation between bathing time and photosensitivity in 8‐methoxypsoralen (8‐MOP) bath PUVA
Author(s) -
Dolezal E.,
Seeber A.,
Hönigsmann H.,
Tanew A.
Publication year - 2000
Publication title -
photodermatology, photoimmunology and photomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.736
H-Index - 60
eISSN - 1600-0781
pISSN - 0905-4383
DOI - 10.1034/j.1600-0781.2000.160407.x
Subject(s) - psoralen , phototoxicity , photosensitivity , bathing , puva therapy , erythema , dermatology , ultraviolet a , medicine , toxicology , psoriasis , chemistry , materials science , optoelectronics , biology , dna , biochemistry , pathology , in vitro
Bath PUVA (psoralen plus ultraviolet A) using 8‐methoxypsoralen has become increasingly popular in recent years as an effective treatment option for a continuously expanding range of skin disorders. Among the various variables of bath PUVA treatment, the impact of bathing time on photosensitivity has never been investigated in detail. We therefore determined the threshold UVA dose for erythema induction after different bathing periods. A marked influence of bathing time on photosensitivity was found. Increasing the soaking period from 5 min to 30 min resulted in a greater than 60% reduction of the minimal phototoxic and minimal perceptible phototoxic dose. Our results demonstrate that the duration of the psoralen bath is a critical parameter in bath PUVA treatment and has a major influence on UVA dose requirements.