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Effect of experimental diabetes on mandible growth in rats
Author(s) -
Giglio Máximo Juan,
Lama Maria Anabel
Publication year - 2001
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1034/j.1600-0722.2001.00032.x
Subject(s) - streptozotocin , mandible (arthropod mouthpart) , diabetes mellitus , medicine , urea , endocrinology , dentistry , chemistry , biology , botany , organic chemistry , genus
The aim of the present work was to assess the effects of experimental diabetes on mandible growth in rats. Experimental diabetes was induced in rats, aged 26 d, by a single dose of 100 mg/kg b.w. of Streptozotocin (STZ). Thirty‐one d post STZ or vehicle injection, the animals were killed. Mandibles were resected to determine Mandibular Skeletal Units dimensions (MSU) and overall mandible growth. Statistical analysis of results revealed, for STZ treated animals as compared to the control group: 1) a decrease in b.w.; 2) an increase in food intake; 3) an increase in glucemia (200%); 4) normal hemoglobin, creatinine and plasma urea values; 5) a reduction in growth of symphyseal (9%), coronoid (16%), and alveolar (13%) heights, condyloid (11%), angular (8%), and base (3%) lengths, and condyloid width (8%). Mandibular length (4%), height (8%) and length of base (6%) were significantly lower in diabetic animals as compared to the control group. No significant differences in length of symphyseal process, alveolar length and height of base were found between groups. Rats on a restricted diet, resulting in a decreased b.w., and the control group exhibited similar mandibular dimensions. These data show that STZ‐induced diabetes reduces mandibular growth, resulting in some deformity of the structure.