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Cell proliferation in skin tumors with ductal differentiation: patterns and diagnostic applications
Author(s) -
Pozo Lucia,
Camacho Francisco,
RiosMartin Juan J.,
DiazCano Salvador J.
Publication year - 2000
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1034/j.1600-0560.2000.027006292.x
Subject(s) - malignancy , pathology , medicine , mitotic index , cylindroma , mitosis , biology , microbiology and biotechnology
The kinetic features of skin tumors with ductal differentiation (TDD) remain mainly unknown. We selected 88 skin TDD (D‐PAS‐positive cuticles) classified according to Murphy and Elder's criteria. Tumors studied included 13 poromas, 12 nodular hidradenomas, 10 cylindromas, 6 spiradenomas, 9 syringomas, 9 chondroid syringomas, 7 porocarcinomas, 15 malignant nodular hidradenomas, and 7 not otherwise specified carcinomas. The same tumor areas were evaluated for mitotic figure counting (MFC) and proliferation rate (PR=MIB‐1 index), screening 10 consecutive high‐power fields (HPFs) in the most cellular areas. Results were recorded by HPF and tumor cellularity, considering both average and standard deviation. Differences were analyzed by Student's t ‐test and analysis of variance (ANOVA) and considered significant if p<0.05. PR was significantly higher in malignant (23.29±12.49) than in benign tumors (3.86±4.44) and in poroma‐nodular hidradenoma (4.99±3.34) than in spiradenoma‐cylindroma‐syringoma (1.91±1.67), but not by malignant tumor type. MFC was significantly higher in malignant (25.52±4.10) than in benign tumors (1.57±0.38), showing porocarcinomas the biggest MFC/10 HPF and malignant nodular hidradenomas the highest MFC/1000 cells. PR and MFC are useful malignancy criteria in skin TDD and should be evaluated by tumor cellularity to avoid potential misinterpretations related with tumor heterogeneity.