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A two‐illness model of bipolar disorder 1
Author(s) -
Joffe Russell T,
Young L Trevor,
MacQueen Glenda M
Publication year - 1999
Publication title -
bipolar disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.285
H-Index - 129
eISSN - 1399-5618
pISSN - 1398-5647
DOI - 10.1034/j.1399-5618.1999.10107.x
Subject(s) - mania , bipolar disorder , depression (economics) , bipolar illness , psychiatry , mood , etiology , psychology , clinical psychology , mood disorders , family history , medicine , anxiety , economics , macroeconomics
The current approach to mood disorders is that bipolar disorder, comprising both mania and depression, is a discreet illness distinct from unipolar depression. This formulation has profoundly influenced the approach to understanding the biology and etiology of these disorders, as well as the manner in which the various phases of bipolar disorder are treated. Our new model suggests that bipolar disorder comprises two distinct illnesses, mania and depression, and that bipolar depression is no different from unipolar depression. Studies of clinical syndromes, course of illness, family history and genetics, biological factors, and treatment response data directly or indirectly support this new model.