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Association of a polymorphism of the ecNOS gene with myocardial infarction in a subgroup of Turkish MI patients
Author(s) -
Çine N,
Hatemi AC,
ErginelUnaltu
Publication year - 2002
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1034/j.1399-0004.2002.610113.x
Subject(s) - genotype , myocardial infarction , medicine , turkish population , polymorphism (computer science) , allele frequency , allele , genotype frequency , cardiology , biology , genetics , gene
In this study we examined a possible association between a 27 base pair (bp)‐repeat polymorphism in intron 4 of the ecNOS gene and myocardial infarction (MI) in a subgroup of the Turkish population. We compared MI and control groups for the frequencies of the ecNOS alleles and their genotypes. The frequency of the ecNOS 4a/a and 4a/b genotypes was found to be significantly higher in the MI group than in the control group. Interestingly, the frequency of the ecNOS 4a/b polymorphism was found to be significantly higher in the selected MI group (patients with no known secondary risk factors) than in the control and non‐selected MI group. We found that the patients with MI had the frequency of the a/a genotype 4.3%, of the a/b genotype 26.6% and the b/b genotype 69.1%. The controls, however, showed only 0.6% for a/a , 18.0% for a/b and 81.4% for the b/b genotype ( P < 0.001; χ 2 = 13.626). In this study, we show that myocardial infarction is associated with one subtype of ecNOS gene polymorphism.