Synthesis of 5- and 6-Carboxy-X-rhodamines | Zendy

Md. Jashim Uddin | Zendy; Lawrence J. Marnett | Zendy

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Synthesis of 5- and 6-Carboxy-X-rhodamines

Author(s) -

Md. Jashim Uddin,

Lawrence J. Marnett

Publication year - 2008

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol801904k

Subject(s) - xanthene , chemistry , conjugated system , molecule , group (periodic table) , in situ , stereochemistry , combinatorial chemistry , photochemistry , organic chemistry , polymer

An efficient route is reported to 5- and 6-carboxy-X-rhodamines (compounds 1 and 2) that contain multiple n-propylene or gamma,gamma-dimethylpropylene groups bridging terminal nitrogen atoms and the central xanthene core. Gram quantities of these dyes are synthesized from inexpensive starting materials. The isolated products are activated by selective transformation of the carboxylic acid group into N-hydroxysuccinimidyl esters in situ and then conjugated with an amino group of a molecule of interest.

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