Open AccessSignaling Natural Products from Human Pathogenic Bacteria
Author(s) -
Zhijuan Hu,
Wenjun Zhang
Publication year - 2019
Publication title -
acs infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.324
H-Index - 39
ISSN - 2373-8227
DOI - 10.1021/acsinfecdis.9b00286
Subject(s) - pathogenic bacteria , virulence , biofilm , biology , bacteria , motility , microorganism , human health , microbiology and biotechnology , antimicrobial , cell signaling , signal transduction , biochemistry , genetics , gene , medicine , environmental health
Natural products from microorganisms are important small molecules that play roles in various biological processes like cellular growth, motility, nutrient acquisition, stress response, biofilm formation, and defense. It is hypothesized that pathogens exploit these molecules to regulate virulence and persistence during infections. Here, we present selected examples of signaling natural products from human pathogenic bacteria that use these metabolites to gain a competitive advantage. Targeting these signaling systems provides novel strategies to antimicrobial treatments.