Open AccessCoproverdine, a Novel, Cytotoxic Marine Alkaloid from a New Zealand Ascidian
Author(s) -
Sylvia Urban,
John W. Blunt,
Murray H. G. Munro
Publication year - 2002
Publication title -
journal of natural products
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.976
H-Index - 139
eISSN - 1520-6025
pISSN - 0163-3864
DOI - 10.1021/np010594z
Subject(s) - alkaloid , bioassay , fractionation , stereochemistry , pharmacognosy , cytotoxic t cell , chemistry , biology , biological activity , traditional medicine , organic chemistry , ecology , biochemistry , in vitro , medicine
The crude extract of a New Zealand ascidian displayed antitumor activity. Bioassay-directed fractionation yielded a novel alkaloid, coproverdine (1). The structure of 1 was assigned on the basis of detailed spectroscopic analysis. Coproverdine (1) was responsible for the antitumor activity of the crude extract.
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