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The aim of this analysis was to evaluate the effects of the presence of the IL-1RA gene polymorphism and  H. pylori  infection on markers of a systemic inflammatory response taking into account virulence markers of this infection. Serum concentrations of interleukin (IL)-6, IL-8, and tumour-necrosis factor (TNF)-α of 479 occasional blood donors were not statistically significantly higher in subjects having antibodies against  H. pylori , or more specifically against CagA and VacA, and being homozygous for the pro-inflammatory IL-1RN*2 allele compared to others after adjustment for covariates. The findings suggest that the possible pro-inflammatory effect of the IL-1RN*2 allele in combination with  H. pylori  infection is limited to the mucosal level.

epidemiology and infection

<i>Helicobacter pylori</i> seropositive subjects do not show a pronounced systemic inflammatory response even in the presence of the interleukin-1 receptor antagonist gene polymorphism

Helicobacter pylori seropositive subjects do not show a pronounced systemic inflammatory response even in the presence of the interleukin-1 receptor antagonist gene polymorphism