Open AccessEnhanced pharmacokinetics of omeprazole when formulated as gastroretentive microspheres along with piperine
Author(s) -
Bindu Madhavi Boddupalli,
Ravinder Nath Anisetti,
R. S. Ramalingam,
Nagulu Malothu
Publication year - 2014
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60427-8
Subject(s) - omeprazole , piperine , cmax , pharmacokinetics , bioavailability , pharmacology , chemistry , microsphere , chromatography , medicine , chemical engineering , engineering
Objective: To investigate the formulation of gastroretentive microspheres of omeprazole along\udwith piperine and estimate the pharmacokinetic parameters in comparison with omeprazole\udalone.\udMethods: In our present investigation, gastroretentive microspheres of omeprazole were prepared\udwith the inclusion of piperine. Pharmacokinetic parameters like Cmax, Tmax and area under curve\udwere estimated by administering the prepared microspheres to rabbits and the results were\udcompared with omeprazole alone.\udResults: There was a significant increase in area under curve from 3.441依1.093 mg·h/mL to 14.422\ud依0.708 mg·h/mL along with an increase in Cmax.\udConclusions: This clearly shows the increased absorption and decreased metabolism of\udomeprazole when administered along with piperine as gastroretentive microspheres