Open AccessEtiology of spontaneous bacterial peritonitis and determination of their antibiotic susceptibility patterns in Iran
Author(s) -
Reza Mirnejad,
Farhad Jeddi,
Jalal Kiani,
Mehdi Khoobdel
Publication year - 2011
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(11)60049-2
Subject(s) - spontaneous bacterial peritonitis , amikacin , cefoxitin , ampicillin , microbiology and biotechnology , coagulase , medicine , ceftriaxone , gentamicin , antibiotics , cephalosporin , penicillin , vancomycin , ascites , biology , staphylococcus , staphylococcus aureus , bacteria , genetics
Objective: To determine the causative agents of spontaneous bacterial peritonitis (SBP) in patients\udwith liver disease and ascites who referred to the pediatrics ward of Tehran Imam Khomeini\udHospital in Iran during January to December 2008. Methods: In this study, from 85 patients\udwith liver disease and ascites, ascite samples were taken and the causative bacterial agents\udwere determined by direct microscopy, culture and biochemical tests. Subsequently, antibiotic\udsusceptibility tests by disk diffusion method (Kirby-Bauer test) were performed on each bacterial\udisolate. Results: Among 85 examined samples, 32 bacterial and 2 yeast agents were isolated.\udAmong bacterial cases, Escherichia coli (31.3%) and coagulase negative Staphylococci (18.8%) were\udthe most predominant and Streptococci and Enterobacteriaceae were the next common agents,\udrespectively. Antibiogram tests revealed that most of isolated coagulase negative Staphylococci\udwere resistant to ampicillin, penicillin, cotrimoxazole and cephalosporin (first generation); and\udmost of the gram negative isolates were resistant to amikacin, gentamicin and vancomycin.\udConclusions: In total agreement with similar studies performed previously in other parts of the\udworld, the present survey indicates that, Escherichia coli and coagulase negative Staphylococci\udare the most common causes of SBP in children and a third generation of cephalosporin such as\udceftriaxone and cefoxitin can be a suitable antibiotic for empirical therapy of children with SBP