Open AccessHepatotoxicity of atenolol therapy - A report of 2 cases
Author(s) -
Somnath Mondal,
Saibal Das,
Sanjib Bandyopadhyay,
Ankur Datta,
Souvik Sardar,
P. Ghosal,
Santanu Kumar Tripathi
Publication year - 2013
Publication title -
journal of acute disease
Language(s) - English
Resource type - Journals
eISSN - 2589-5516
pISSN - 2221-6189
DOI - 10.1016/s2221-6189(13)60137-7
Subject(s) - atenolol , medicine , drug , liver dysfunction , hepatic dysfunction , liver function , anesthesia , pharmacology , blood pressure
AbstractThis case report highlights atenolol induced episodes of chronic and acute hepatotoxicities in 2 elderly hypertensive patients. The 1st patient manifested liver dysfunction after 8 months of 50 mg daily atenolol therapy and in the 2nd patient liver dysfunction was revealed within 3 weeks of 100 mg daily atenolol intake. There was no evidence of any other possible hereditary, traumatic, surgical, metabolic, infective, organic, or pathologic causes giving rise to these conditions. Possibilities of drug interactions were carefully ruled out and these episodes of hepatotoxicities were ‘probably’ drug (atenolol) induced, as depicted by CIOMS/RUCAM scale. Withdrawal of the offending drug resulted in reversal of the diseased states. Routine liver function tests may be warranted in patients on atenolol therapy