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Update of REACH‐1 and MERIT‐HF clinical trials in heart failure
Author(s) -
Mylona Panayiota,
Cleland John G.F.
Publication year - 1999
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/s1388-9842(99)00022-7
Subject(s) - heart failure , medicine , metoprolol , bosentan , cardiology , clinical trial , randomized controlled trial , endothelin receptor , intensive care medicine , receptor
Abstract Background: This article reviews the design and results of REACH‐1 (Research on Endothelin Antagonism in Chronic Heart Failure) and MERIT (Metoprolol controlled and Extended release, Randomised Intervention Trial in congestive Heart Failure), two recently reported clinical trials that investigated, respectively, the role of a non‐selective endothelin antagonist (bosentan) and of a β‐selective blocker for the treatment of heart failure. Results: The REACH‐1 trial demonstrated that initiation of bosentan therapy is associated with an increased risk of worsening heart failure. However, long‐term therapy with bosentan may have improved symptoms and favourably altered the progression of heart failure. The MERIT‐HF clinical trial indicated that β‐blockade using metoprolol confers a significant beneficial effect on total mortality in patients with stable chronic heart failure.