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Glial cell line‐derived neurotrophic factor (GDNF) as a defensive molecule for neurodegenerative disease: a tribute to the studies of Antonia Vernadakis on neuronal–glial interactions
Author(s) -
Bohn Martha C.,
Kozlowski Dorothy A.,
Connor Bronwen
Publication year - 2000
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/s0736-5748(00)00036-8
Subject(s) - glial cell line derived neurotrophic factor , gdnf family of ligands , neurotrophic factors , neuroscience , neurturin , dopaminergic , ciliary neurotrophic factor , biology , dopamine , genetics , receptor
Abstract Research stemming from interests in neuronal–glial interactions has led to the identification of a number of novel trophic factors, such as the dopaminergic neurotrophic factor glial cell line‐derived neurotrophic factor (GDNF). Delivery of the GDNF gene to rat models of Parkinson's disease suggests a potential clinical use of GDNF gene therapy for humans with this disease. This review article briefly summarizes the history of GDNF and the effects of GDNF gene delivery prior to or after a lesion of the rat nigrostriatal system.