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Submolecular resolution of single macromolecules with atomic force microscopy
Author(s) -
Czajkowsky Daniel M.,
Shao Zhifeng
Publication year - 1998
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(98)00461-x
Subject(s) - macromolecule , atomic force microscopy , resolution (logic) , microscopy , nanotechnology , chemistry , biophysics , materials science , chemical physics , physics , optics , computer science , biology , biochemistry , artificial intelligence
The intrinsically high signal‐to‐noise ratio of atomic force microscopy (AFM) permits structural determination of individual macromolecules to, at times, subnanometer resolution directly from unprocessed images, avoiding the conditions and possible consequences of averaging over an ensemble of molecules. In this article, we will review some of the most recent achievements in imaging single macromolecules with AFM.