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The protein phosphatase 2A B′‐regulatory subunit par1p is implicated in regulation of the S. pombe septation initiation network
Author(s) -
Le Goff Xavier,
Buvelot Stéphanie,
Salimova Ekaterina,
Guerry Frédéric,
Schmidt Susanne,
Cueille Nathalie,
Cano Elena,
Simanis Viesturs
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)03047-2
Subject(s) - protein subunit , protein phosphatase 2 , schizosaccharomyces pombe , phosphatase , microbiology and biotechnology , protein phosphatase 1 , biology , chemistry , genetics , yeast , gene , phosphorylation , saccharomyces cerevisiae
In order to identify regulators of the Schizosaccharomyces pombe septation initiation network (SIN), which signals the onset of cell division, we have isolated extragenic suppressors of mutations in the GTPase spg1p, which is a central element in this pathway. One of these encodes the protein phosphatase 2A (PP2A) B′‐regulatory subunit par1p. Loss of par1p function rescues mutants in cdc11 , cdc7 , and spg1 , but no other SIN mutants. Our data suggest that PP2A‐par1p acts as a negative regulator of SIN signalling.