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Involvement of the NF‐κB pathway in the transforming properties of the TEL–Jak2 leukemogenic fusion protein
Author(s) -
Constantino Rosa Santos Susana,
Monni Richard,
Bouchaert Isabelle,
Bernard Olivier,
Gisselbrecht Sylvie,
Gouilleux Fabrice,
Penard-Lacronique Virginie
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02452-8
Subject(s) - protein kinase b , stat5 , signal transduction , microbiology and biotechnology , chromosomal translocation , nf κb , fusion protein , pi3k/akt/mtor pathway , cancer research , kinase , apoptosis , chemistry , cell growth , biology , biochemistry , gene , recombinant dna
Constitutively active tyrosine kinases are frequently expressed in various types of human leukemias as the result of chromosomal translocations. The TEL–Jak2 fusion oncoprotein possesses transforming properties in both animal and cellular models, that are tightly dependent on Stat5 activation. In the IL‐3‐independent TEL–Jak2‐transformed Ba/F3 cells, activation of the PI‐3K/Akt pathway appears essential to cell proliferation. Here we report a sustained activation of NF‐κB factors in Ba/F3 cells, which inhibition dramatically impairs cell viability, indicating that NF‐κB signaling exerts a major role in the anti‐apoptotic activities of TEL–Jak2 oncoprotein.