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Histone deacetylase complexes: functional entities or molecular reservoirs
Author(s) -
Khochbin Saadi,
Kao Hung-Ying
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02327-4
Subject(s) - histone , chromatin , chromatin remodeling , histone deacetylase , chemistry , biochemistry , histone deacetylase 2 , transcription factor , enzyme , acetylation , microbiology and biotechnology , computational biology , biology , dna , gene
Recent investigations have allowed the identification of an increasing number of distinct nuclear multi‐component complexes containing several types of enzymatic activity. Many of the complexes containing histone deacetylases are believed to control transcription and chromatin remodeling. We suggest here that at least some of these abundant complexes are likely to be ‘molecular reservoirs’ of dynamic composition that exchange factors with other less abundant and functional complexes, according to specific required activities.