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Signaling crosstalk underlying synergistic induction of astrocyte differentiation by BMPs and IL‐6 family of cytokines
Author(s) -
Yanagisawa Makoto,
Nakashima Kinichi,
Takizawa Takumi,
Ochiai Wataru,
Arakawa Hirokazu,
Taga Tetsuya
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)02095-6
Subject(s) - leukemia inhibitory factor , stat3 , astrocyte , stat protein , microbiology and biotechnology , bone morphogenetic protein , chemistry , glial fibrillary acidic protein , crosstalk , transcription factor , bone morphogenetic protein 2 , signal transduction , biology , interleukin 6 , cytokine , immunology , neuroscience , central nervous system , biochemistry , immunohistochemistry , physics , gene , optics , in vitro
We here show that bone morphogenetic protein (BMP) 7 acted in synergy with the distinct type of cytokines, leukemia inhibitory factor (LIF) and interleukin (IL) 6 that are in the IL‐6 family, to induce astrocyte differentiation from neuroepithelial cells as assessed by expression of glial fibrillary acidic protein (GFAP). In this synergistic action, transcription factors, Smads and STAT3 (for signal transducer and activator of transcription 3) activated by respective group of cytokines, as well as a transcriptional coactivator p300 were essential. Taken together with our previous finding that the synergistic astrocyte induction by BMP2 and LIF is attributed to the complex formation of Smads and STAT3 bridged by p300, it is conceivable that this complex formation is a mechanism utilized in common by two different types of cytokines belonging to the BMP and IL‐6 families in order to synergistically induce astrocyte differentiation.