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Population pharmacokinetics of sirolimus in kidney transplant patients
Author(s) -
Ferron Geraldine M.,
Mishina Elena V.,
Zimmerman James J.,
Jusko William J.
Publication year - 1997
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1016/s0009-9236(97)90192-2
Subject(s) - sirolimus , pharmacokinetics , volume of distribution , population , ciclosporin , urology , pharmacology , antibacterial agent , medicine , therapeutic drug monitoring , oral administration , chemistry , kidney , antibiotics , biochemistry , environmental health
Objective To characterize the dose‐related pharmacokinetics of the immunosuppressant agent sirolimus (formerly rapamycin) in kidney transplant patients by use of two‐stage and nonlinear mixed‐effect model population methods. Methods Patients ( n = 36) from three centers (Germany, the United Kingdom, and Sweden) who received steady‐state oral doses of cyclosporine (ciclosporin) were assessed after single oral administration of sirolimus at doses of 3, 5, 10, and 15 mg/m 2 . Plasma and whole blood sirolimus samples were analyzed by a high‐performance liquid chromatographic/mass spectrophotometric method. Simultaneous fitting used biexponential functions with intercept/slope or clearance/volume terms, as well as first‐order absorption (k a ) and a lag‐time. Results The nonlinear mixed‐effect model method (P‐Pharm) provided a better characterization of sirolimus kinetics, especially for the absorption and distribution phases where fewer data were available per patient. Sirolimus distribution between whole blood and plasma was concentration‐independent, with a mean blood/plasma ratio (coefficient of variation) of 30.9 (48.5%). Elimination was not influenced by dose, as shown by estimates of the terminal half‐life of 63 hours (27.5%) and apparent oral blood clearance of 8.9 L/hr (38.2%). Sirolimus distribution parameters were influenced by body weight and surface area. Sirolimus was rapidly absorbed, as shown by the absorption lag‐time of 0.27 hour (35.1%), and k a of 2.77 hr −1 (48.4%). The concomitant administration of sirolimus and cyclosporine did not reveal any pharmacokinetic interaction. Conclusion This report provides an initial population pharmacokinetics of sirolimus in kidney transplant recipients receiving cyclosporine concurrently. Sirolimus blood and plasma pharmacokinetics were biexponential and linear for doses from 3 to 15 mg/m 2 . No pharmacokinetic interaction was found between sirolimus and cyclosporine. Clinical Pharmacology & Therapeutics (1997) 61 , 416–428; doi: