Open AccessLncRNA-CASC7 enhances corticosteroid sensitivity via inhibiting the PI3K/AKT signaling pathway by targeting miR-21 in severe asthma
Author(s) -
Jianhua Liu,
Chen Li,
Changhong Zhang,
Zhihua Zhang
Publication year - 2019
Publication title -
pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.826
H-Index - 22
eISSN - 2531-0437
pISSN - 2531-0429
DOI - 10.1016/j.pulmoe.2019.07.001
Subject(s) - medicine , pi3k/akt/mtor pathway , asthma , protein kinase b , corticosteroid , sensitivity (control systems) , signal transduction , cancer research , microbiology and biotechnology , biology , electronic engineering , engineering
Asthma, a common chronic inflammatory disease, is treated with corticosteroid in most cases, but corticosteroid resistance in severe asthma patients seriously impairs the therapeutic effects. LncRNA-CASC7 inhibits cell proliferation and enhances drug sensitivity, but the molecular mechanisms of corticosteroid resistance in severe asthma are still unknown.
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