Open AccessMeaningful associations in the adolescent brain cognitive development study
Author(s) -
Anthony Steven Dick,
Daniel A. Lopez,
Ashley L. Watts,
Steven G. Heeringa,
Chase Reuter,
Hauke Bartsch,
Chun Fan,
David N. Kennedy,
Clare E. Palmer,
Andrew T. Marshall,
Frank Haist,
Samuel W. Hawes,
Thomas E. Nichols,
M Deanna,
Terry L. Jernigan,
Hugh Garavan,
Steven Grant,
Vani Pariyadath,
Elizabeth A. Hoffman,
Michael C. Neale,
Elizabeth A. Stuart,
Martin P. Paulus,
Kenneth J. Sher,
Wesley K. Thompson
Publication year - 2021
Publication title -
neuroimage
Language(s) - English
Resource type - Journals
eISSN - 1095-9572
pISSN - 1053-8119
DOI - 10.1016/j.neuroimage.2021.118262
Subject(s) - biobank , cohort , neurocognitive , population , mental health , ethnic group , cognition , cohort study , medicine , psychology , demography , gerontology , psychiatry , environmental health , pathology , sociology , anthropology , biology , genetics
The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children's health in the United States. A cohort of n= 11,880 children aged 9-10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, ethnicity, household income, and parental education. Data collected include assessments of health, mental health, substance use, culture and environment and neurocognition, as well as geocoded exposures, structural and functional magnetic resonance imaging (MRI), and whole-genome genotyping. Here, we describe the ABCD Study aims and design, as well as issues surrounding estimation of meaningful associations using its data, including population inferences, hypothesis testing, power and precision, control of covariates, interpretation of associations, and recommended best practices for reproducible research, analytical procedures and reporting of results.