Open AccessADAMTS‐3, ‐13, ‐16, and ‐19 levels in patients with habitual abortion
Author(s) -
Pekcan Meryem Kuru,
Sarıkaya Esma,
Tokmak Aytekin,
Alışık Murat,
Alkan Afra,
Özakşit Gülnur,
Erel Özcan
Publication year - 2017
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/j.kjms.2016.10.010
Subject(s) - adamts , medicine , thrombospondin , demographics , metalloproteinase , prospective cohort study , disintegrin , area under the curve , abortion , pregnancy , gastroenterology , matrix metalloproteinase , demography , genetics , sociology , biology
Abstract A disintegrin‐like and metalloproteinase domain with thrombospondin‐type 1 motifs (ADAMTS) protein superfamily includes 19 secreted metalloproteases. Proteolytic substrates of ADAMTS enzymes have been linked to reproductive function. The aim of this study was to investigate serum ADAMTS‐3, ‐13, ‐16, and ‐19 levels in women with habitual abortions compared with those in healthy controls. A total of 86 women were enrolled in this prospective case‐control study. ADAMTS‐3, ‐13, ‐16, and ‐19 values were recorded and analyzed in association with demographic and clinical parameters. There were no statistically significant differences between the two groups in terms of demographics. No statistically significant differences were observed between the groups with regard to ADAMTS‐13 and ‐19 levels ( p > 0.05). However, ADAMTS‐3 and ‐16 were significantly higher in the study group than in the control group ( p = 0.004 and p = 0.005, respectively). To estimate habitual abortions using an area under receiver operating characteristic curve analysis, the cutoff values for ADAMTS‐3 and ‐16 were found to be 87.28 ng/mL (sensitivity, 64.44%; specificity 68.29%) and 15.75 ng/mL (sensitivity, 66.67%; specificity 68.29%), respectively. In conclusion, the pregnancy‐loss rate seems to be affected by both ADAMTS‐3 and ‐16.