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IC‐P‐099: SUBJECT FACTORS RELATED TO CSF DYNAMICS CONFOUND MEASUREMENT OF CSF BIOMARKERS IN ADNI
Author(s) -
Townley Ryan A.,
Gunter Jeffrey L.,
Senjem Matthew L.,
Wiste Heather J.,
Graff-Radford Jonathan,
Jack Clifford R.,
Jones David T.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4942
Subject(s) - striatum , biomarker , positron emission tomography , neuroimaging , magnetic resonance imaging , cerebrospinal fluid , imaging biomarker , medicine , pathology , oncology , neuroscience , nuclear medicine , psychology , radiology , biology , biochemistry , dopamine
WMT composite(p1⁄40.005). In WMT individually pt205 significantly predicted FA and DR for the FM(FA p1⁄40.01; DR p1⁄40.037) and PCC(FA p1⁄40.0023; DR p1⁄40.003). Conclusions: Only pt205 predicted WMT integrity and correlated with measures of demyelination. Disruption of WMTs was predominantly observed in posterior callosal fibers, which is a projection from the precuneus, known to be an area of early tau PET deposition in ADAD. These results suggest a role for primary white matter degeneration in ADAD pathology.