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O4‐13‐06: ASSOCIATIONS BETWEEN MULTIMORBIDITY AND CSF AMYLOID: CROSS‐SECTIONAL ANALYSIS OF THE EUROPEAN PREVENTION OF ALZHEIMER'S DEMENTIA (EPAD) COHORT
Author(s) -
Stirland Lucy E.,
Russ Tom C.,
Ritchie Craig W.,
Terrera Graciela Muniz
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4817
Subject(s) - dementia , cohort , medicine , cohort study , cross sectional study , logistic regression , multimorbidity , association (psychology) , psychiatry , comorbidity , psychology , disease , pathology , psychotherapist
between GM and WM volumes and exposure to NO, NO2, PM2.5, and PM10 are shown in Figure 1. Details of specific areas are described in Tables 1&2. Higher exposures to NO, NO2 and PM10 are statistically significant associated with smaller GM volumes of the precuneus and the temporal middle lobe. Higher exposures to NO2, NO and PM2.5 are associated with bigger WM volumes in the corpus callosum and the bilateral parahippocampal areas. Conclusions: In a population of cognitively healthy adults with increased risk of AD, exposure to air pollution is suggested to be associated with changes in GM and WM volume of specific brain areas, potentially related to AD susceptibility. Further research is granted to elucidate themechanisms involved in such associations. O4-13-06 ASSOCIATIONS BETWEEN MULTIMORBIDITYAND CSFAMYLOID: CROSS-SECTIONAL ANALYSIS OF THE EUROPEAN PREVENTION OF ALZHEIMER’S DEMENTIA (EPAD) COHORT Lucy E. Stirland, Tom C. Russ, Craig W. Ritchie, Graciela Muniz Terrera and the EPAD Consortium, University of Edinburgh, Edinburgh, United Kingdom; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom; Centre for Dementia Prevention, University of Edinburgh, Edinburgh, United Kingdom. Contact e-mail: l.stirland@ed.ac.uk