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P2‐156: EFFECTS OF LEPTIN ON HIPPOCAMPUS VOLUME AND COGNITIVE PERFORMANCE
Author(s) -
Huhn Sebastian,
Beyer Frauke,
Zhang Rui,
Lampe Leonie,
Luck Tobias,
Riedel-Heller Steffi G.,
Kratzsch Jürgen,
Schroeter Matthias L.,
Loeffler Markus,
Stumvoll Michael,
Villringer Arno,
Witte A. Veronica
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.843
Subject(s) - leptin , hippocampus , medicine , leptin receptor , overweight , endocrinology , obesity , psychology
VENs were the same in AD compared to controls. Interestingly, while the ratio of GABRQ-expressing neurons was significantly lower in bvFTD (p1⁄40.03) compared to controls, this ratio was significantly increased in AD compared to controls (p1⁄40.05). Conclusions:We show that GABRQ-expressing neurons are selectively vulnerable in bvFTD. Our data indicates that in AD cases this group of neurons is spared in the ACC, and suggests that other Layer 5 neurons are targeted by neurodegeneration in AD. The selective vulnerability of VENs in bvFTD is shared with the surrounding GABRQ-expressing neurons, implicating that a larger neuronal group specific to ACC and FI is linked to social-emotional behavior.