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P1‐380: MRI CLASSIFIERS CHARACTERIZE MILD TRAUMATIC BRAIN INJURY IN SYMPTOMATIC AND PRESYMPTOMATIC STAGES AND DIFFERENTIATE FROM ALZHEIMER'S DISEASE–RELATED IMPAIRMENT
Author(s) -
Matthews Dawn C.,
Andrews Randolph D.,
Lukic Ana S.,
Mishra Virendra R.,
Banks Sarah Jane,
Cummings Jeffrey L.,
Bernick Charles
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.388
Subject(s) - chronic traumatic encephalopathy , traumatic brain injury , atrophy , medicine , dementia , neuroscience , cognitive impairment , psychology , physical medicine and rehabilitation , audiology , pathology , cognition , concussion , disease , poison control , psychiatry , injury prevention , environmental health
Figure 1. Voxel based comparison of healthy volunteers separated into young (18 to 36) and older (38 to 71) age groups, compared to unimpaired and impaired retired boxers. Higher CV1 scores reflect greater expression of the pattern of atrophy shown at left. Young and older HV do not differ, Dix U. Meiberth, Xiaochen Hu, Ann-Katrin Schild, Annika Spottke, Frederic Brosseron, Katharina Buerger, Klaus Fliessbach, Michael T. Heneka, Ingo Kilimann, Christoph Laske, Oliver Peters, Josef Priller, Anja Schneider, Stefan J. Teipel, Jens Wiltfang, MichaelWagner, Emrah D€uzel, Frank Jessen and the DELCODE Study Group, Department of Psychiatry and Psychotherapy, University Hospital Cologne, Cologne, Germany; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department of Neurology, University of Bonn, Bonn, Germany; Department of Neurodegeneration and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany; Institute for Stroke and Dementia Research (ISD), Klinikum der Universit€at M€unchen, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; University Hospital Bonn, Bonn, Germany; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of T€ubingen, T€ubingen, Germany; German Center for Neurodegenerative Diseases (DZNE), T€ubingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany; Department of Psychiatry and Psychotherapy, Charit e-Universitaetsmedizin Berlin, Berlin, Germany; Charit e Universit€atsmedizin Berlin & Berlin Institute of Health, Berlin, Germany; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany; Department of Psychiatry and Psychotherapy, University Medical Center, Goettingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany. Contact e-mail: dix.meiberth@uk-koeln.de