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O4‐04‐05: FIBER‐TRACT–SPECIFIC DECLINE IN WHITE‐MATTER INTEGRITY DURING THE ADULT LIFESPAN AND PRECLINICAL ALZHEIMER'S DISEASE: RESULTS FROM THE DALLAS LIFESPAN BRAIN STUDY AND DIAN
Author(s) -
Araque Caballero Miguel A.,
Park Denise C.,
Song Zhuang,
Levin Johannes,
Bateman Randall J.,
Morris John C.,
Jucker Mathias,
Danek Adrian,
Yakushev Igor,
Benzinger Tammie L.S.,
Ewers Michael
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2931
Subject(s) - white matter , dementia , voxel , diffusion mri , psychology , alzheimer's disease , medicine , disease , oncology , neuroscience , magnetic resonance imaging , radiology
Figure 1. (A) Global network efficiency as a function of age for the whole sample (n 1⁄4 449), with a quadratic fit. (B) Global network efficiency as a function of age for Ab– (blue triangles) and Ab+ subjects (red dots). Miguel A. Araque Caballero, Denise C. Park, Zhuang Song, Johannes Levin, Randall J. Bateman, John C. Morris, Mathias Jucker, Adrian Danek, Igor Yakushev, Tammie L. S. Benzinger, Michael Ewers and DIAN, Institute for Stroke and Dementia Research, Ludwig-Maximilians-Universit€at, Munich, Germany; The University of Texas at Dallas, Dallas, TX, USA; The Center for Vital Longevity, The University of Texas at Dallas, Dallas, TX, USA; University of Munich, Munich, Germany; Washington University, St. Louis, MO, USA; Knight Alzheimer’s Disease Research Center, St. Louis, MO, USA; German Center for Neurodegenerative Diseases, Tuebingen, Germany; Department of Neurology, Ludwig-Maximilians-Universit€at,Munich, Germany; Technische Universitaet Muenchen, Munich, Germany; Washington University in St. Louis School of Medicine, St. Louis, MO, USA. Contact e-mail: michael.ewers@med.uni-muenchen.de