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P4‐105: A SIMPLE METHOD FOR DEFINING ATROPHY SUBTYPES IN INDIVIDUAL SUBJECTS ACROSS THE ALZHEIMER'S DISEASE SPECTRUM
Author(s) -
Charil Arnaud,
Risacher Shan L.,
Shcherbinin Sergey,
Saykin Andrew J.,
Schwarz Adam J.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2509
Subject(s) - atrophy , psychology , hippocampal formation , subtyping , neocortex , cognition , neuroscience , correlation , pathology , audiology , medicine , geometry , mathematics , computer science , programming language
sensorimotor SBR) was observed in bilateral medial frontal cortex, left caudate and left thalamus. Positive correlation between FDG uptake and sensorimotor SBR (corrected for cognitive SBR) was observed in bilateral visual association Cortex (Fig. 1). Conclusions: These findings confirm that altered cerebral glucose metabolism is associated with nigrostriatal degeneration in PD. The association between metabolism and nigrostriatal degeneration in the cognitive part of the striatum is in line with known cortico-striatal connections.