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P1‐235: SEX‐SPECIFIC ASSOCIATIONS OF SERUM BILE ACIDS WITH BRAIN ATROPHY DURING AGING: DIFFERENTIAL EFFECTS OF CONJUGATION AND GUT MICROBIAL METABOLISM
Author(s) -
Varma Vijay R.,
Chuang Yi-Fang,
An Yang,
Huang Chiung-Wei,
Oommenn Anup,
Sonntag Denise,
Armstrong Nicole,
Davatzikos Christos,
Legido-Quigley Cristina,
Resnick Susan M.,
Thambisetty Madhav
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.240
Subject(s) - cholic acid , chenodeoxycholic acid , medicine , lithocholic acid , bile acid , endocrinology , atrophy , taurocholic acid , chemistry
increased expression. The gene product is known to interact with APP, thus, its increased level could be associated with Ab deposition. Conclusions:We performed neuron-specific ChIP-seq of sporadic AD with H3K4me3 antibody and found two differentially bound regions. These regions are associated with neuronal functions or Ab metabolism, suggesting that histone modifications are deeply associated with AD pathophysiology.