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P3‐608: HIGH‐NORMAL FASTING PLASMA GLUCOSE IN ADOLESCENCE IS ASSOCIATED WITH POORER BRAIN STRUCTURE AND FUNCTION IN MIDLIFE: THE BOGALUSA HEART STUDY
Author(s) -
Carmichael Owen T.,
Stuchlik Patrick,
Pillai Sreekrishna R.,
Dhullipudi Ram,
Madden Anna,
Martin Shane,
Hsia Daniel,
Fonseca Vivian A.,
Bazzano Lydia
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1975
Subject(s) - medicine , plasma glucose , endocrinology , diabetes mellitus , brain structure and function , cognition , psychiatry
restrospective comparative study of 130 MCI patients (n1⁄4 80) (M1⁄476, 74 years old; ds1⁄46.8 years) and healthy older adults (n1⁄450) (M1⁄471.51 years (ds1⁄48.92) Instruments: Questionnaire of Social Demographic Data (built ad hoc), Questionnaire of Social Participation. Results: Results reveal that when comparing the groups, statistically significant differences in favor of the group of healthy older adults were found in their involvement in: Social Activities (F(130, 1) 1⁄4 3.72, p < .05), Recreational Activities (F(130, 1) 1⁄4 3.55, p < .05), Educational Activities (F(130, 1) 1⁄4 7.09, p < .01) before retirement and Recreational Activities (F(130, 1) 1⁄4 3.02, p < .05), Educational Activities (F(130, 1) 1⁄4 13.03, p< .01) at the present time. Conclusions:These results agree with other studies which identified the factors that promote healthy cognitive aging in older adults. Within the framework of cognitive reserve, participation in social, recreational, and educational activities play a differential and important role in the enhancement of cognitive abilities, being important buffers of cognitive deterioration in the aging process. The present study coincides with other researches, and adds empirical evidence of interest for the clinical and scientific fields of healthy cognitive ageing. Figure 2. White mater hyperintensity (WMH) volume at a midlife MRI was significantly elevated among those who had mean FPG above the median value during the pre-20 period. P3-608 HIGH-NORMAL FASTING PLASMA