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P3‐588: BRAIN‐DERIVED NEUROTROPHIC FACTOR AND THE INCIDENCE OF COGNITIVE IMPAIRMENT IN THE EPIDEMIOLOGY OF HEARING LOSS STUDY
Author(s) -
Paulsen Adam J.,
Schubert Carla R.,
Cruickshanks Karen J.,
Carlsson Cynthia M.,
Chappell Richard J.,
Klein Barbara E.K.,
Klein Ronald,
Tsai Michael Y.,
Dalton Dayna S.,
Pinto Alex
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1954
Subject(s) - brain derived neurotrophic factor , dementia , incidence (geometry) , medicine , population , epidemiology , rotterdam study , cumulative incidence , neurotrophic factors , risk factor , psychology , audiology , disease , cohort , physics , receptor , environmental health , optics
# children 1 child 2,350 902 Ref Ref Ref 2 children 4,607 1,672 0.93 (0.86, 1.01) 0.94 (0.86, 1.01) 0.94 (0.87, 1.02) 3 children 3,534 1,258 0.88 (0.81, 0.96) 0.89 (0.81,0.97) 0.88 (0.81, 0.96) 4 children 3,885 1,351 0.88 (0.80, 0.95) 0.87 (0.80, 0.95) 0.86 (0.79, 0.94) # miscarriages Continuous 6,751 2,338 1.08 (1.05, 1.12) 1.08 (1.04, 1.11) 1.08 (1.04, 1.11) 0 miscarriages 1,669 512 Ref Ref Ref 1 miscarriage 3,077 1,094 1.21 (1.09, 1.35) 1.22 (1.09, 1.35) 1.21 (1.09, 1.35) 2 miscarriages 1,246 446 1.17 (1.03, 1.34) 1.17 (1.03, 1.34) 1.17 (1.03, 1.33) 3 miscarriages 759 286 1.47 (1.27, 1.71) 1.45 (1.25, 1.67) 1.43 (1.23, 1.65) Age at menarche 9 years old 29 14 1.40 (0.83, 2.37) 1.42 (0.84, 2.41) 1.39 (0.82, 2.36) 10-13 years old 3451 1402 Ref Ref Ref 14-15 years old 1484 610 0.99 (0.90, 1.09) 1.01 (0.91, 1.11) 1.00 (0.91, 1.11) 16 years old 789 341 1.22 (1.03, 1.44) 1.25 (1.05, 1.47) 1.27 (1.07, 1.50) Age at menopause 41 years old 1219 483 1.06 (0.94, 1.20) 1.07 (0.94, 1.21) 1.08 (0.96, 1.22) 42-46 years old 1376 561 1.03 (0.92, 1.16) 1.05 (0.94, 1.18) 1.06 (0.95, 1.19) 47-49 years old 1050 424 0.95 (0.84, 1.07) 0.95 (0.84, 1.07) 0.96 (0.85, 1.08) 50 years old 1495 678 Ref Ref Ref