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P3‐357: HIPPOCAMPAL VOLUME AND FUNCTIONAL CONNECTIVITY DIFFERENTIATE BETWEEN COGNITIVELY NORMAL INDIVIDUALS WITH AND WITHOUT SUBJECTIVE MEMORY COMPLAINTS
Author(s) -
Zajac Lauren,
Koo Bang-Bon,
Tripodis Yorghos,
Mian Asim,
Steinberg Eric,
Mez Jesse,
Alosco Michael L.,
Stern Robert A.,
Killiany Ronald
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.1719
Subject(s) - default mode network , hippocampus , hippocampal formation , logistic regression , audiology , psychology , cognition , neuroimaging , neuropsychology , functional magnetic resonance imaging , magnetic resonance imaging , brain size , resting state fmri , neuroscience , medicine , physical medicine and rehabilitation , radiology
relationships between hippocampal volume obtained by 7T MRI and memory function were observed in clinically healthy older adults. Since weak associations were also found in the control region, volumes of other cortical brain regions will be analyzed to exclude a global effect. Further analyses will include APOE ε4 carrier status to test if negative associations are restricted to individuals at high risk for AD. Ongoing analyses will also include patients diagnosed with mild cognitive impairment and AD.